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The vaccine specifically used to prevent meningococcal disease among adolescents is MCV4, which stands for the quadrivalent meningococcal conjugate vaccine. This vaccine is designed to protect against four strains of Neisseria meningitidis, which is the bacterium responsible for causing meningococcal disease. Meningococcal disease can lead to serious conditions such as meningitis and sepsis, particularly in adolescents and young adults.

MCV4 is recommended for preteens and teens, typically administered at ages 11-12 years with a booster dose given at age 16. This schedule is important as it ensures optimal protection during the years when adolescents are at higher risk for the disease, particularly in communal settings like college dorms.

In contrast, the other vaccines listed have different targets: HepB protects against hepatitis B virus, DTaP is for diphtheria, tetanus, and pertussis, and Varicella provides immunity against chickenpox. None of these vaccines are specific for preventing meningococcal disease.